Clinical Studies

Clinical evidence supporting the use of wound protectors has appeared in many publications worldwide. Applied Medical is proud to offer a comprehensive wound protection solution that facilitates improved outcomes for a multitude of surgical specialties.

Efficacy of a Dual-Ring Wound Protector for Prevention of Surgical Site Infections After Pancreaticoduodenectomy in Patients with Intrabiliary Stents: A Randomized Clinical Trial

Excerpt: “Among adult patients with intrabiliary stents, the use of a dual-ring wound protector during [pancreaticoduodenectomy] significantly reduces the risk of incisional SSI (surgical site infection).”

Reference: Bressan AK, Aubin JM, Martel G, et al. Efficacy of a Dual-ring Wound Protector for Prevention of Surgical Site Infections After Pancreaticoduodenectomy in Patients With Intrabiliary Stents: A Randomized Clinical Trial. Ann Surg. 2018;268(1):35-40. doi:10.1097/SLA.0000000000002614

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Wound Protectors in Reducing Surgical Site Infections in Lower Gastrointestinal Surgery: An Updated Meta-Analysis

Excerpt: “. . . We demonstrated evidence of a subgroup difference where dual-ring wound protectors reduced SSIs while single-ring retractors did not, which provides greater insight in the choice of wound protection devices.

“Our meta-analysis found that dual-ring wound protectors reduce the odds of SSI (surgical site infection) in patients undergoing lower gastrointestinal surgery. . . .”

Reference: Zhang L, Elsolh B, Patel SV. Wound protectors in reducing surgical site infections in lower gastrointestinal surgery: an updated meta-analysis. Surg Endosc. 2018;32(3):1111-1122. doi:10.1007/s00464-017-6012-0

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Wound Protectors Reduce Surgical Site Infection: A Meta-Analysis of Randomized Controlled Trials

Excerpt: “. . . Our study suggests that the use of wound protectors decreases the risk of SSI by 45%. Our number needed to treat suggests that only 10 patients would have to be treated intraoperatively with a wound protector to prevent 1 SSI. . . .

“Impervious plastic wound protectors reduce the risk of SSI (surgical site infection) when employed in non-trauma-related gastrointestinal and biliary tract surgery. Wound protectors represent a safe and simple intervention that may reduce postoperative morbidity and mortality. . . .”

Reference: Edwards JP, Ho AL, Tee MC, Dixon E, Ball CG. Wound protectors reduce surgical site infection: a meta-analysis of randomized controlled trials. Ann Surg. 2012;256(1):53-59. doi:10.1097/SLA.0b013e3182570372

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Plastic Wound Retractors as Bacteriological Barriers in Gastrointestinal Surgery: A Prospective Multi-institutional Trial

Excerpt: “In summary, use of a plastic wound retractor may result in reduced enteric bacterial colonization of the surgical incision site during gastrointestinal surgery. Reduced colonization of the surgical incision site by enteric bacteria due to the use of a plastic wound retractor should result in a reduction in SSI (surgical site infection) following gastrointestinal surgery.”

Reference: Reference: Mohan HM, McDermott S, Fenelon L, et al. Plastic wound retractors as bacteriological barriers in gastrointestinal surgery: a prospective multi-institutional trial. J Hosp Infect. 2012;81(2):109-113. doi:10.1016/j.jhin.2012.03.005

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ALEXIS O Ring Retractor vs Conventional Wound Protection for the Prevention of Surgical Site Infections in Colorectal Resections

Excerpt: “The ALEXIS wound retractor is more effective in preventing SSI (surgical site infection) in elective colorectal resections compared with conventional methods.”

Reference: Cheng KP, Roslani AC, Sehha N, et al. ALEXIS O-Ring wound retractor vs conventional wound protection for the prevention of surgical site infections in colorectal resections(1). Colorectal Dis. 2012;14(6):e346-e351. doi:10.1111/j.1463-1318.2012.02943.x

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A Wound Protector Shields Incision Sites from Bacterial Invasion

Excerpt: “These results suggest that the [wound protector] protects an incision site from bacterial invasion.”

“. . . [W]e consider that the low incidence of SSI (surgical site infection) may have resulted from the protective effects of the [wound protector]. . . .”

Reference: Horiuchi T, Tanishima H, Tamagawa K, et al. A wound protector shields incision sites from bacterial invasion. Surg Infect (Larchmt). 2010;11(6):501-503. doi:10.1089/sur.2009.072

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Barrier Wound Protection Decreases Surgical Site Infection in Open Elective Colorectal Surgery: A Randomized Clinical Trial

Excerpt: “In this study the use of barrier wound protection in elective open colorectal resectional surgery resulted in a clinically significant reduction in incisional surgical site infections. Barrier wound protection of this nature should be considered routine in this type of surgery.”

Reference: Reid K, Pockney P, Draganic B, Smith SR. Barrier wound protection decreases surgical site infection in open elective colorectal surgery: a randomized clinical trial. Dis Colon Rectum. 2010;53(10):1374-1380. doi:10.1007/DCR.0b013e3181ed3f7e

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Use of Wound-Protection System and Postoperative Wound-Infection Rates in Open Appendectomy

Excerpt: “. . . Our data support the use of a wound-protection device in open surgery as a method of decreasing postoperative wound-infection rates. This technique could be applied to a broader spectrum of open surgical procedures and ultimately reduce the economic and emotional burden of a preventable SSI (surgical site infection).”

Reference: Lee P, Waxman K, Taylor B, Yim S. Use of Wound-Protection System and Postoperative Wound-Infection Rates in Open Appendectomy: A Randomized Prospective Trial. Arch Surg. 2009;144(9):872–875. doi:10.1001/archsurg.2009.151

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Randomized, Controlled Investigation of the Anti-Infective Properties of the Alexis Retractor/Protector of Incision Sites

Excerpt: “. . . The results of this study demonstrate that wound infection decreased significantly in the With Alexis retractor group.”

Reference: Horiuchi T, Tanishima H, Tamagawa K, et al. Randomized, controlled investigation of the anti-infective properties of the Alexis retractor/protector of incision sites. J Trauma. 2007;62(1):212-215. doi:10.1097/

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